The Mayo Clinic is a non-profit medical organization dedicated to diagnosing and treating complex diseases and illness. The commercial website for the organization (mayoclinic.com) is focused on providing health and medical information for the general public. In contrast, mayoclinic.org is focused on providing medical services through one of their organizational outlets, while mayoclinic.edu is focused on education and research. Mayoclinic.com has over six and a half million viewers per month, with a slight tilt towards a female audience.

The website has a vast array of comprehensive guides for viewers. Viewers can access the Diseases and Conditions section, which contains a detailed list of known diseases ordered by alphabetical listing or area of medical discipline (allergy, digestive, cancer, etc). This section also includes a symptom checker, where viewers can enter their symptoms and receive a list of possible diagnoses, and a first-aid guide.

Viewers accessing the Drugs and Supplements database will find information on thousands of different medications, vitamins and herbal supplements. The information includes brand names, descriptions, proper use and possible concerns, such as drug interactions and age restrictions.

The website also contains guides on treatment options for a number of ailments and conditions and a comprehensive collection of guides and tools for healthy living, including stop smoking assistance, pregnancy, and stress relief. Tools include a huge Q and A section on a wide variety of health issues covering common misconceptions and popular questions in the media concerning the medical industry. Another set of tools can be seen in the Health Tools section, which contains various calculators (calories, target heart rates, and other), self assessments and medical quizzes. Viewers can also watch a variety of slide shows, videos, and podcasts on any of the topics listed above.